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Fletta eftir efnisorði "Breast cancer"
Atriði 1-20 af 25
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(MDPI AG, 2019-11-01)Mutations in BRCA1 result in predisposal to breast and ovarian cancers, but many variants exist with unknown clinical significance (VUS). One is BRCA1 c.4096+3A>G, which affects production of the full-length BRCA1 transcript, while augmenting transcripts ... -
(2019-12-11)Background: Breast Cancer 1 gene (BRCA1) is known to be inactivated in breast tumors by promoter methylation. Tumor cells in patients carrying a germline mutation in BRCA1 are sensitive to cytotoxic drugs that cause DNA double strand breaks. However, ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-11)Germline mutations in BRCA2 increase the risk of breast and ovarian cancer. The BRCA2 protein is involved in maintaining genomic stability through its roles in DNA double strand break repair and protection of stalled replication forks. The BRCA2 gene ...
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(Springer Science and Business Media LLC, 2019-10-16)Human breast cancer is believed to arise in luminal progenitors within the normal breast. A subset of these are double positive (DP) for basal and luminal keratins and localizes to a putative stem cell zone within ducts. We here present a new protocol ...
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(Cold Spring Harbor Laboratory, 2019-01-28)Circular RNAs (circRNAs) are a class of RNAs that is under increasing scrutiny, although their functional roles are debated. We analyzed RNA-seq data of 348 primary breast cancers and developed a method to identify circRNAs that does not rely on unmapped ...
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(Impact Journals, LLC, 2019-07-23)Estrogen receptor-positive breast cancer is subdivided into subtypes LuminalA and LuminalB, based on different expression patterns. MicroRNA-190b has been reported to be up-regulated in estrogen receptor-positive breast cancers. In this study we aimed ...
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(Public Library of Science (PLoS), 2018-05-30)Recent studies indicate that lifestyle factors in early life affect breast cancer risk. We therefore explored the association of high consumption of meat, milk, and whole grain products in adolescence and midlife, on breast cancer risk. We used data ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2016-12)Background and aims: Previous studies in geothermal and volcanic areas have shown high risk of certain types of cancers. The aim was to study the association between residence in geothermal areas and the incidence and mortality of cancer in ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-08)The microenvironment is increasingly being recognized as a key player in supporting cancer progression. Therefore, investigating heterotypic interactions between cancer cells and their microenvironment is important for improving our understanding ...
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(Public Library of Science (PLoS), 2019-08-23)Background: Fusion genes result from genomic structural changes, which can lead to alterations in gene expression that supports tumor development. The aim of the study was to use fusion genes as a tool to identify new breast cancer (BC) genes with a ...
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(2021-11-19)Breast cancer is the cancer most often diagnosed in women. MicroRNAs (MIRs) are short RNA molecules that bind mRNA resulting in their downregulation. MIR21 has been shown to be an oncomiR in most cancer types, including breast cancer. Most of the effects ...
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(Public Library of Science (PLoS), 2020-04-14)Breast cancer (BC) is the most prevalent type of cancer in women in western countries. BC mortality has not declined despite early detection by screening, indicating the need for better informed treatment decisions. Therefore, a novel noninvasive ...
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(Wiley, 2020-07-27)Melphalan flufenamide (hereinafter referred to as “melflufen”) is a peptide-conjugated drug currently in phase 3 trials for the treatment of relapsed or refractory multiple myeloma. Due to its lipophilic nature, it readily enters cells, where it is ...
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(Elsevier BV, 2017-06)Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes place during EMT are still limited. ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2023-03-30)Breast cancer is the most frequently diagnosed cancer today, with approximately 2.3 million new cases for the year 2020. Regardless of gender, these diagnoses represent 11.7% of all cases. For women, breast cancer falls under roughly one-third of cancer ...
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(2022-06-21)Background: Experimental studies indicate that neuroendocrine pathways might play a role in progression of breast cancer. We aim to test the hypothesis that somatic mutations in the genes of neuroendocrine pathways influence breast cancer prognosis, ...
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(Springer Science and Business Media LLC, 2020-09-26)Purpose of Review: Long-term survival has increased significantly in breast cancer patients, and cardiovascular side effects are surpassing cancer-related mortality. We summarize risk factors, prevention strategies, detection, and management of ...
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(Springer Science and Business Media LLC, 2020-04-22)Metastatic progression is the leading cause of mortality in breast cancer. Invasive tumor cells develop invadopodia to travel through basement membranes and the interstitial matrix. Substantial efforts have been made to characterize invadopodia molecular ...
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(Springer Science and Business Media LLC, 2019-12-10)Background: An increasing number of women are evaluated for potential breast cancer and may experience mental distress during evaluation. We aim to assess the risks of psychiatric disorders and cardiovascular diseases during the diagnostic workup of ...
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(Wiley, 2020-07-14)Little is known about how health insurance policies, particularly in developing countries, influence breast cancer prognosis. Here, we examined the association between individual health insurance and breast cancer-specific mortality in China. We included ...
Atriði 1-20 af 25